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Job Offer: Animal and Human iPSC Models of Neurodevelopmental Disorders:Rutgers Robert Wood Johnson Medical School

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Animal and Human iPSC Models of Neurodevelopmental Disorders

Rutgers Robert Wood Johnson Medical School

Details
Published:
August 17, 2018
Job location:
Piscataway, New Jersey

income:
Consistent with NIH guidelines
Type:
Full Time - practiced
Discipline:
Academic / Research
Required suitable education
Doctorate

 

Basic Research and Education Training Postdoctoral Fellowship. We are interested in knowledge the mechanisms that cause disorders of brain development, such as autism, schizophrenia, and depression. We study the cellular and molecular mechanisms by which autism risk and developmental genes and environmental factors regulate neural stem cell proliferation, fate determination, and differentiation in the developing brain and iPSC-NPC models of neuropsychiatric disorders. Analyses focus on neurogenesis, apoptosis, neurite outgrowth, cell migration, and gene expression in transgenic animal models as well as human iPSC-derived NPCs. In animal models, we assess the cerebral cortex, hippocampus, amygdala, cerebellum, and monoamine systems. Studies are performed in embryos in utero, postnatal and adult animals, and human neural stem cell cultures using gene over/under expression techniques, in vivo electroporation, growth and immune factors, toxicants, and transgenic mutants. This NIH-IRACDA supported 3-yr fellowship (http://rwjms.rutgers.edu/research/postdoc/inspire/) supports 70% research mentoring and 30% training in educational methods. candidates must be U.S. citizens or Permanent Residents. Competitive candidates will have neuroscience or developmental practice, and facility with techniques such as design/use of molecular constructs, immunochemistry and image processing, neural stem cell technology, cell biology, or biochemistry. Fellows work in a large, highly collaborative neuroscience community at Rutgers Robert Wood Johnson Medical School (RWJMS) and Rutgers University that includes experts in animal and human genetics, behavior, iPSC technologies, learning and memory, neurotrophins, glial cell biology, neurophysiology. We are located only 45 min from New York City and 15 min from Princeton. appropriate candidates have an MD and/or PhD in Neuroscience, Cell, Molecular, or Developmental Biology. AA/EOE. Send CV, research statement, 2-3 references: Emanuel DiCicco-Bloom, MD, Neuroscience & Cell Biology, Robert Wood Johnson Medical School, 683 Hoes Lane, Piscataway, NJ 08854; E-mail: E-Mail: diciccem@rutgers.edu
Genestine M, Lin L, Durens M, Yan Y, Jiang Y, Prem S, Bailoor K, Kelly B, Sonsalla PK, Matteson PG, Silverman J, Crawley JN, Millonig JH, DiCicco-Bloom E. (2015) Engrailed-2 (En2) deletion produces multiple neurodevelopmental defects in monoamine systems, forebrain structures and neurogenesis and behavior. Hum Mol Genet 2015 Jul 28. pii ddv301
Williams M, Prem S, Zhou X, Matteson P, Leung L, Lu CW, Pang Z, Brzustowicz L, Millonig JH, DiCicco-Bloom E. (2018) Rapid Detection of Neurodevelopmental Phenotypes In Human Neural Precursor Cells (NPCs). J Vis Exp. 2018 Mar 2;(133). doi: 10.3791/56628. PMID: 29553565

MD and/or PhD in Neuroscience, Cell, Molecular, or Developmental Biology
practice and facility with techniques such as animal brain and embryo anatomy/dissection, design/use of molecular constructs, immunochemistry, fluorescence microscopy and image analysis, stereology, neural stem cell technology, cell and tissue culture, molecular biology, western analyses, cell biology, or biochemistry

NOTES:

Additional income Information: Additional support includes travel funds to scientific meetings; computer; workshops on writing, mentoring, curriculum (see http://rwjms.rutgers.edu/research/postdoc/inspire/)

Internal Number: ASD-EDB

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About Rutgers Robert Wood Johnson Medical School
I have broad practice with basic and translational research on neurodevelopmental disorders including animal models and human induced pluripotent stem cells. As active child neurologist, my professional activities involve promoting clinical translation of basic neuroscience research through federal, professional, and advocacy organizations, while pursuing neurodevelopmental research. I review autism-related grants and advise advocacy organizations for several decades including National Alliance for Autism Research , Autism Speaks, Autism Tissue Program, Autism Science Foundation , International Rett Syndrome Fdn, Autistica, NIH (Chair, Developmental Brain Disorders) and Department of Defense (CDMRP). My basic research focuses on gene, growth factor, and toxicant regulation of neurogenesis during brain development, using cell and animal models of neurodevelopmental disorders, including autism, schizophrenia, and environmental teratogens. We have defined mechanisms by which growth factors, genes, and drugs affect proliferation, survival, and fate of stem cells from cerebral cortex, hippocampus, and cerebellum in culture and in vivo. We are defining functions of autism-connected gene, ...Engrailed-2, in cerebellar/hindbrain development; secondary effects on forebrain structure and function; and drug rescue of behavioral deficits. Similar studies focus on CNV 16p11.2 deletion mice. In other studies, we have created human Neural Precursor Cells (NPC) from lymphocyte-derived induced pluripotent stem cells of children with idiopathic autism, to identify common neurobiological signatures. Further, we are comparing common phenotypes defined in idiopathic autism NPCs to genetically defined NPCs from CNV 16p11.2 deletion individuals with autism. This new era of exploring neuropsychiatric conditions in human neurons may provide more significant cellular and molecular pathways on which to target therapeutic interventions that may be “personalized” to the needs of the specific individual.

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Job Category: Other [ View All Other Jobs ]
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Salary: Unspecified
Degree: Unspecified
Experience (year): Unspecified
Job Location:  Piscataway, New Jersey
Company Type Employer
Post Date: 09/19/2018 / Viewed 1 times
Contact Information
Company: Rutgers Robert Wood Johnson Medical School
Contact Email: diciccem@rutgers.edu


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