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Job Opportunity: Head of Computational Sciences:

Job description:

Beam Therapeutics


Head of Computational Sciences

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Job detail

We are pursuing an innovative, collaborative and accomplished scientist to lead our Computational Sciences team to support the development of novel base editing therapies using our next-generation, state-of-the-art technology.



  • Establish, manage and motivate a team of computational scientists to support all computational biology applications necessary to develop and execute a compelling portfolio of base editable targets.

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  • Create and implement a suite of computational biology tools, programs and hardware to support all gene editing research activities, which may include:

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    • Use genome-scale data to conduct disease mapping and other statistical analyses to generate target hypotheses. Collaborate with research teams to prioritize and validate drug discovery targets

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    • Use and enhance existing bioinformatics tools to analyze NGS data of edited sites and to establish algorithms for the optimal, automated selection of guide RNAs

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    • Use protein modeling tools such as Rosetta to develop protein models of Cas to support protein engineering of variants and, where appropriate, to help characterize and select appropriate mutations for targeted proteins

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    • Communicate scientifically rigorous findings via verbal and written communications, visualizations, and presentations

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    • Apply or develop new tools or data-mining techniques for integrative analysis and visualization of large data-sets


Qualifications :

  • A Ph.D. in Bioinformatics, Computer Science, Biology, Genetics or equivalent, and a minimum of 10 years of practice in computational biology and genomics required.

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  • managery practice

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  • practice with molecular research techniques (qPCR, ddPCR, NGS library prep) and gene editing (CRISPR/Cas9) is ideal

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  • Proficiency in evaluating large-scale genomic datasets

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  • Robust expertise of one or more programming language (eg. Python, C++, R, etc) and of protein modeling software (ideally Rosetta)

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  • Strong scientific background and publication record with proven high levels of performance

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  • practice with machine learning algorithms and data mining methods

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  • Familiarity with pathway analysis

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  • practice with cloud computing is a plus

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  • capability to work independently while also building relationships with colleagues

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  • capability to adapt to increasing scope and complexity of work brought on by growth/change and helps others manage through change.

Directions to apply : submit your resume to

Qualified candidates will be contacted immediately so that we can share more information about the technology platform!

Job Information

  • : Cambridge, Massachusetts, United States

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  • : 39960691

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  • : July 22, 2018

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  • : Head of Computational Sciences

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  • : Beam Therapeutics

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  • : Bioinformatics

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  • : Full-Time

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  • : Indefinite

    About Beam Therapeutics

    Beam Therapeutics is pioneering the use of CRISPR base editing to develop precision genetic medicines that treat disease, one letter at a time.

    Base editing is a new category in CRISPR gene editing. Our groundbreaking technology allows us to make specific edits to base pairs in DNA or RNA. We use the power of a CRISPR enzyme to target a single location within the genome out of billions of bases (A, C, G, T). At that site, our technology is capable of precisely editing just a single base, without cutting the DNA or RNA strands.

    Base editors can deliver precise, programmable changes to a target gene sequence, enabling a wide variety of therapeutic strategies. To create base editor therapeutics, Beam is working with a variety of validated and emerging technologies for delivering base editors to different tissues and cell types.

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    Job Category: Other [ View All Other Jobs ]
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    Job Location: Cambridge, Massachusetts
    Company Type Employer
    Post Date: 07/22/2018 / Viewed 53 times
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